Atrophy of Ipsilesional Hippocampal Subfields Vary Over First Year After Ischemic Stroke

MS Khlif; E Werden; LJ Bird; N Egorova-Brumley; A Brodtmann

Journal article

Atrophy of Ipsilesional Hippocampal Subfields Vary Over First Year After Ischemic Stroke

MS Khlif, E Werden, LJ Bird, N Egorova-Brumley, A Brodtmann

Journal of Magnetic Resonance Imaging | WILEY | Published : 2022

DOI: 10.1002/jmri.28009

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Abstract

Background: The structural integrity of hippocampal subfields has been investigated in many neurological disorders and was shown to be better associated with cognitive performance than whole hippocampus. In stroke, hippocampal atrophy is linked to cognitive impairment, but it is unknown whether the hippocampal subfields atrophy differently. Purpose: To evaluate longitudinal hippocampal subfield atrophy in first year poststroke, in comparison with atrophy in healthy individuals. Study Type: Cohort. Subjects: A total of 92 ischemic stroke (age: 67 ± 12 years, 63 men) and 39 healthy participants (age: 69 ± 7 years, 24 men). Field Strength/Sequence: A3 T/T1-MPRAGE, T2-SPACE, and T2-FLAIR. Assess..

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University of Melbourne Researchers

Emilio Werden Author

Natalia Egorova-Brumley Author

Amy Brodtmann Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by: NHMRC GTN1020526, GTN1045617 (A.B.), GTN1094974; Brain Foundation; Wicking Trust; Collie Trust; Sidney and Fiona Myer Family Foundation; ARC DE180100893 (N.E.B.); Heart Foundation Future Leader Fellowship (100784, A.B.).